Purpose: to fill soup granule preparation composition is: radix astragali, rhizoma ligustici wallichii, salvia miltiorrhiza, epimedium, fructus alpiniae oxyphyllae, calamus, polygala, red flower. Under laboratory conditions for the extraction of medicinal materials of main effective component technology integration and exploration on the research and the preparation process of granular, finding the best the best preparation process. Method: this topic through the experiment research, according to the characteristics of the medicine effective component, respectively using water extraction, alcohol extraction, steam distillation extraction method to extract, the extracted solvent dosage, extraction time and other factors in the process of optimization research, the major effective components flavonoids and the extraction of safflower yellow pigment amount as an index, using the principle of uniform design method based on statistical design of single factor experiment, and according to the single factor experiment, the optimum extraction conditions of orthogonal experiment design, determine the best process, and select the proper excipients, made into granules. Conclusion: using 70% ethanol, 120 min, 12 times the amount of ethanol raises flavonoids effect is good; Ultrasonic extraction of 15 min, and then with 21 times of water decoction extraction of safflower yellow pigment 100 minutes of the best effect; Water vapor distillation were separated and 150 min works best. Keywords: granules, extraction technology, preparation process, the water extraction, alcohol extraction, steam distillation, the orthogonal experiment, total flavonoids, safflower yellow pigment, the essential oil
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