英语翻译丙二酸衍生物是形成配合物的良好配体,特别是在生物配位化学中具有重要意义.丙二酸是一个羧基酞酶的弱阻化剂,它与这种
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Malonic acid derivatives is the formation of complexes of ligand good,especially in the coordination of biological chemistry is of great significance.Meldrum is a carboxyl-phthalocyanine weak resistance agent,with the activity of this enzyme metal ion (Mg2 + Mg2 +) formed fairly stable chelate,and its derivatives benzene methyl malonic acid is a strong resistance agent.In this capacity on the activity of the difference may be due to metal ions and the enzyme bond strength between the larger reason.Phenylethyl than malonic acid methyl malonic acid benzene over a methylene,metal complexes of stability and performance is a lack of research.After literature,we can see ligand and metal ion bonding strength and bioactivity depends not only on the distribution of atoms coordination,also coordinate with non-hydrophobic groups and hydrophobic groups and the coordination between the atoms of the free rotation of the chain length.Suitable hydrophobic groups between the hydrophobic interaction with the same increase in metal ion bonding strength.From a structural point of view,phenylethyl malonic acid is with the above characteristics.To this end,we synthesized the functional ligand,and for the first time in the ligand in two alkane / water mixture in a medium,2 ionization constants.Furthermore,the synthesis of its solid complexes with DNA.Buses its role fully demonstrates the malonic acid derivatives is a good ligand.

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