表示地点时可以互换.如:
This is the table where/at which my family have meals everyday.这就是我们一家人天天吃饭的桌子.
The house where/in which I wrote my article lies on the hill.这座房子座落在山腰,我在这座房子里写了我的文章.
如果不是表示地点,一般不能互换.如:
The little creature in which scientists are interested is known as ET.
这里"be interested in"是固定词组.