灏辨槸杩欎釜,鎵撳紑缃戝潃.寰堟竻妤欬br/>Homo sapiens serine/threonine kinase 11 (STK11),RefSeqGene on chromosome 19

NCBI Reference Sequence:NG_007460.1

FASTA Graphics

LOCUS NG_007460 29637 bp DNA linear PRI 26-OCT-2010

DEFINITION Homo sapiens serine/threonine kinase 11 (STK11),RefSeqGene on

chromosome 19.

ACCESSION NG_007460

VERSION NG_007460.1 GI:170014710

KEYWORDS RefSeqGene.

SOURCE Homo sapiens (human)

ORGANISM Homo sapiens

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;

Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;

Catarrhini; Hominidae; Homo.

COMMENT REVIEWED REFSEQ:This record has been curated by NCBI staff.The

reference sequence was derived from AC011544.6 and AC004221.2.

This sequence is a reference standard in the RefSeqGene project.

Summary:This gene,which encodes a member of the serine/threonine

kinase family,regulates cell polarity and functions as a tumor

suppressor.Mutations in this gene have been associated with

Peutz-Jeghers syndrome,an autosomal dominant disorder

characterized by the growth of polyps in the gastrointestinal

tract,pigmented macules on the skin and mouth,and other

neoplasms.Alternate transcriptional splice variants of this gene

have been observed but have not been thoroughly characterized.

[provided by RefSeq].

PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP

1-24712 AC011544.6 21192-45903

24713-29637 AC004221.2 282-5206

FEATURES Location/Qualifiers

source 1..29637

/organism="Homo sapiens"

/mol_type="genomic DNA"

/db_xref="taxon:9606"

/chromosome="19"

/map="19p13.3"

gene 2411..3022

/gene="LOC729119"

/note="high-mobility group box 2 pseudogene"

/pseudo

/db_xref="GeneID:729119"

gene 5001..27637

/gene="STK11"

/gene_synonym="LKB1; PJS"

/note="serine/threonine kinase 11"

/db_xref="GeneID:6794"

/db_xref="HGNC:11389"

/db_xref="MIM:602216"

mRNA join(5001..6405,17619..17702,18526..18615,19575..19707,

19783..19919,20415..20542,21151..21208,22187..22374,

25656..25865,26795..27637)

/gene="STK11"

/gene_synonym="LKB1; PJS"

/product="serine/threonine kinase 11"

/transcript_id="NM_000455.4"

/db_xref="GI:58530881"

/db_xref="GeneID:6794"

/db_xref="HGNC:11389"

/db_xref="MIM:602216"

exon 5001..6405

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=1

CDS join(6116..6405,17619..17702,18526..18615,19575..19707,

19783..19919,20415..20542,21151..21208,22187..22374,

25656..25849)

/gene="STK11"

/gene_synonym="LKB1; PJS"

/EC_number="2.7.11.1"

/note="polarization-related protein LKB1; renal carcinoma

antigen NY-REN-19; serine/threonine-protein kinase LKB1;

serine/threonine-protein kinase 11"

/codon_start=1

/product="serine/threonine-protein kinase 11"

/protein_id="NP_000446.1"

/db_xref="GI:4507271"

/db_xref="CCDS:CCDS45896.1"

/db_xref="GeneID:6794"

/db_xref="HGNC:11389"

/db_xref="MIM:602216"

STS 8732..8913

/gene="STK11"

/gene_synonym="LKB1; PJS"

/standard_name="REU1905"

/db_xref="UniSTS:257089"

exon 17619..17702

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=2

exon 18526..18615

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=3

exon 19575..19707

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=4

exon 19783..19919

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=5

exon 20415..20542

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=6

exon 21151..21208

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=7

exon 22187..22374

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=8

STS 22882..23072

/gene="STK11"

/gene_synonym="LKB1; PJS"

/standard_name="RH104368"

/db_xref="UniSTS:98693"

exon 25656..25865

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=9

exon 26795..27637

/gene="STK11"

/gene_synonym="LKB1; PJS"

/inference="alignment:Splign:1.39.8"

/number=10

gene complement(29150..>29637)

/gene="C19orf26"

/gene_synonym="DOS; MGC40084"

/note="chromosome 19 open reading frame 26"

/db_xref="GeneID:255057"

/db_xref="HGNC:28617"

mRNA complement(29150..>29637)

/gene="C19orf26"

/gene_synonym="DOS; MGC40084"

/product="chromosome 19 open reading frame 26"

/transcript_id="NM_152769.2"

/db_xref="GI:148886715"

/db_xref="GeneID:255057"

/db_xref="HGNC:28617"